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| Urinary trypsinogen-2 for diagnosing acute pancreatitis: a meta-analysis |
| Tao Jin, Wei Huang, Kun Jiang, Jun-Jie Xiong, Ping Xue, Muhammad A Javed, Xiao-Nan Yang and Qing Xia |
Chengdu, China
Author Affiliations: Sichuan Provincial Pancreatitis Center, Department of Integrated Traditional Chinese and Western Medicine (Jin T, Jiang K, Xue P, Yang XN and Xia Q) and Department of Hepato-Biliary-Pancreatic Surgery (Xiong JJ), West China Hospital, Sichuan University, Chengdu 610041, China; NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, University of Liverpool, Liverpool L69 3BX, UK (Huang W and Javed MA)
Corresponding Author: Qing Xia, MD, PhD, Sichuan Provincial Pancreatitis Center, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China (Tel: 86- 28-85423373; Fax: 86-28-85423373; Email: xiaqing@medmail.com.cn) |
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Abstract BACKGROUND: Currently, serum amylase and lipase are the most popular laboratory markers for early diagnosis of acute pancreatitis with reasonable sensitivity and specificity. Urinary trypsinogen-2 (UT-2) has been increasingly used but its clinical value for the diagnosis of acute pancreatitis and post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis has not yet been systematically assessed.
DATA SOURCES: A comprehensive search was carried out using PubMed (MEDLINE), Embase, and Web of Science for clinical trials, which studied the usefulness of UT-2 as a diagnostic marker for acute pancreatitis. Sensitivity, specificity and the diagnostic odds ratios (DORs) with 95% confidence interval (CI) were calculated for each study and were compared with serum amylase and lipase. Summary receiver-operating curves were conducted and the area under the curve (AUC) was evaluated.
RESULTS: A total of 18 studies were included. The pooled sensitivity and specificity of UT-2 for the diagnosis of acute pancreatitis were 80% and 92%, respectively (AUC=0.96, DOR=65.63, 95% CI: 31.65-139.09). The diagnostic value of UT-2 was comparable to serum amylase but was weaker than serum lipase. The pooled sensitivity and specificity for the diagnosis of post-ERCP pancreatitis were 86% and 94%, respectively (AUC=0.92, DOR=77.68, 95% CI: 24.99-241.48).
CONCLUSIONS: UT-2 as a rapid test could be potentially used for the diagnosis of post-ERCP pancreatitis and to an extent, acute pancreatitis. Further studies are warranted to confirm these results.
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2013, Vol. 12 
