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Samaritan donor interchange in living donor liver transplantation |
See Ching Chan, Kenneth SH Chok, William W Sharr, Albert CY Chan, Simon HY Tsang, Wing Chiu Dai and Chung Mau Lo |
Hong Kong, China
Author Affiliations: Department of Surgery (Chan SC, Chok KSH, Sharr WW, Chan ACY, Tsang SHY, Dai WC and Lo CM); and State Key Laboratory for Liver Research (Chan SC and Lo CM), The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China
Corresponding Author: See Ching Chan, Li Shu Fan Medical Foundation Professor in Surgery, Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China (Tel: 852-22553025; Fax: 852-28175475; Email: seechingchan@gmail.com) |
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Abstract BACKGROUND: In order to overcome ABO blood group incompatibility, paired donor interchange has been practised in living donor liver transplantation. Liver transplantations using grafts donated by Samaritan living donors have been performed in Europe, North America, South Korea, and Hong Kong. Such practice is clearly on strong biological grounds although social and psychological implications could be far-reaching. Local experience has been satisfactory but is still limited. As few centers have this arrangement, its safety and viability are still being assessed under a clinical trial setting.
METHODS: Here we report a donor interchange involving an ABO-compatible pair with a universal donor and an ABO-incompatible pair with a universal recipient. This matching was not only a variation but also an extension of the donor interchange scheme.
RESULTS: The four operations (two donor hepatectomies and two recipient operations) were successful. All the two donors and the two recipients recovered well. Such donor interchange further supports the altruistic principle of organ donation in contrast to exchange for a gain.
CONCLUSIONS: Samaritan donor interchange certainly taxes further the ethical challenge of donor interchange. Although this practice has obvious biological advantages, such advantages have to be weighed against the potential increase in potential psychological risks to the subjects in the interchange. Further ethical and clinical evaluations of local and overseas experiences of donor interchange should guide future clinical practice in utilizing this potential organ source for transplantation.
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