|
|
|
| Blood group type antigens in pancreatic intraductal papillary mucinous neoplasms |
| Adriana Handra-Luca |
Bobigny, France and Baltimore, USA
Author Affiliations: Departments of Pathology, Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA; and APHP Universite Paris Nord Sorbonne Cite-Sce Anatomie Pathologique, GHU Avicenne, 125 rue Stalingrad, Bobigny 93000, France (Handra-Luca A)
Corresponding Author: Adriana Handra-Luca, MD, PhD, APHP Universite Paris Nord Sorbonne Cite-Sce Anatomie Pathologique, GHU Avicenne, 125 rue Stalingrad, Bobigny 93000, France (Tel: 0033-1-48955555ext2047; Fax: 0033-1-48955602; Email: adriana.handra-luca@avc.aphp.fr) |
|
|
|
|
Abstract BACKGROUND: There are few data on blood group (BG) types and types of pancreatic cancers. The aims of this study were to study BG types and BG-antigens in pancreatic intraductal papillary mucinous neoplasms (IPMNs).
METHODS: BG type and tumor BG-antigen (glycoprotein) expression (studied by immunohistochemistry on tissue microarrays) were analyzed with regard to characteristics of 101 surgically resected pancreatic IPMNs.
RESULTS: Non-O BG type predicted invasive carcinoma independently from high serum CA19-9 and male gender. BG type A was observed more frequently in women than in men. Chronic pancreatitis was more frequently seen in patients with BG type B or AB. Aberrant tumor expression (with regard to BG type) of loss of A antigen expression type occurred in 15.0% of IPMNs and of loss of B antigen expression type in 62.5% of IPMNs. Intraneoplasm BG-antigen expression was not related to dysplasia grade or invasion.
CONCLUSION: The results of the study suggest that in pancreatic IPMN, non-O BG type predicted invasive carcinoma, whereas for intratumor BG-antigen expression no specific patterns were detected with regard to the progression of glandular epithelial dysplasia or invasion.
|
|
|
|
|
|
|
|
|
2014, Vol. 13 
