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| Familial chylomicronemia syndrome related chronic pancreatitis: a single-center study |
| Gurhan Sisman, Yusuf Erzin, Ibrahim Hatemi, Erkan Caglar, Salih Boga, Vikesh Singh and Hakan Senturk |
Istanbul, Turkey
Author Affiliations: Division of Gastroenterology, Istanbul University Cerrahpasa Medical Faculty, Istanbul 34100, Turkey (Sisman G, Erzin Y, Hatemi I and Caglar E); Division of Gastroenterology, ?i?li Etfal Education and Research Hospital, Istanbul 34365, Turkey (Boga S); Division of Gastroenterology, Johns Hopkins Hospital, Baltimore 1830 E, USA (Singh V); Division of Gastroenterology, Bezmialem School of Medicine, Istanbul 34100, Turkey (Senturk H)
Corresponding Author: Yusuf Erzin, MD, Division of Gastroenterology, Istanbul University Cerrahpasa Medical Faculty, Istanbul 34100, Turkey (Tel: 90-532-2655008; Fax: 90-212-2525057; Email: dryusuferzin@yahoo.com) |
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Abstract BACKGROUND: Hypertriglyceridemia induces acute recurrent pancreatitis, but its role in the etiology of chronic pancreatitis (CP) is controversial. This study aimed to evaluate the clinical, laboratory and radiological findings of 7 patients with CP due to type 1 hyperlipidemia compared to CP patients with other or undefined etiological factors.
METHODS: We retrospectively analyzed the clinical, laboratory and radiological findings of 7 CP patients with type 1 hyperlipidemia compared to CP patients without hypertriglyceridemia. These 7 patients had multiple episodes of acute pancreatitis and had features of CP on abdominal CT, endoscopic retrograde cholangiopancreatography and/or endoscopic ultrasonography.
RESULTS: All CP patients were classified into two groups: a group with type 1 hyperlipidemia (n=7) and a group with other etiologies (n=58). The mean triglyceride level was 2323±894 mg/dL in the first group. Age at the diagnosis of CP in the first group was significantly younger than that in the second group (16.5±5.9 vs 48.3±13.5, P<0.001). The number of episodes of acute pancreatitis in the first group was significantly higher than that in the second group (15.0±6.8 vs 4.0±4.6, P=0.011). The number of splenic vein thrombosis in the first group was significantly higher than that in the second group (4/7 vs 9/58, P=0.025). Logistic regression analysis found that younger age was an independent predictor of CP due to hypertriglyceridemia (r=0.418, P=0.000).
CONCLUSIONS: Type 1 hyperlipidemia appears to be an etiological factor even for a minority of patients with CP. It manifests at a younger age, and the course of the disease might be severe.
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2014, Vol. 13 
