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| Risk factors for postoperative bile leakage: a retrospective single-center analysis of 411 hepatectomies |
| Fabrizio Panaro, Lisa Hacina, Hassan Bouyabrine, Al-Warith Al-Hashmi, Astrid Herrero and Francis Navarro |
Montpellier, France
Author Affiliations: Department of General and Liver Transplant Surgery, Montpellier University Hospital, College of Medicine, 80 Avenue Augustin Fliche 34295, Montpellier-Cedex 5, France (Panaro F, Hacina L, Bouyabrine H, Al-Hashmi A, Herrero A and Navarro F)
Corresponding Author: Fabrizio Panaro, MD, PhD, Department of Surgery, Division of Transplantation, Montpellier University Hospital, College of Medicine, 80 Avenue Augustin Fliche 34295, Montpellier-Cedex 5, France (Tel: +33-0467336733; Fax: +33-0467337623; Email: f-panaro@chu-montpellier.fr) |
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Abstract BACKGROUND: The primary focus of the study was to analyze the risk factors for bile leakage after hepatectomy for benign or malignant tumors.
METHODS: A total of 411 patients who had undergone hepatectomy between December 2006 and December 2011 were retrospectively analyzed. The severity of bile leakage was graded according to the ISGLS classification. Twenty-eight pre- and postoperative parameters were analyzed.
RESULTS: The overall bile leakage incidence was 10.2% (42/411). The severity of the leakage was classified according to the ISGLS classification. Bile leakage was detected early in case of abdominal drainage (11.4% vs 1.9%, P=0.034). It prolonged the time of hospitalization (16 vs 9 days, P=0.001). In all patients, wedge resection was associated with a higher incidence of bile leakage in contrast to anatomical resections (25.6% vs 4.1%, P<0.0001) regardless of the underlying liver disease. Furthermore, total vascular exclusion increased risk of bile leakage (P=0.008).
CONCLUSIONS: Bile leakage as a major issue after hepatic resection is related to the postoperative morbidity and the hospitalization time. It is associated with non-anatomical resection and a total vascular exclusion.
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2016, Vol. 15 
