|
|
|
| Role of microRNA in liver regeneration |
| Peng-Sheng Yi, Ming Zhang and Ming-Qing Xu |
Chengdu, China
Author Affiliations: Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China (Yi PS, Zhang M and Xu MQ)
Corresponding Author: Ming-Qing Xu, MD, PhD, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China (Tel/Fax: +86-28-85422870; Email: xumingqing0018@163.com) |
|
|
|
|
Abstract BACKGROUND: Liver regeneration is a complex process. microRNAs (miRNAs) are short, single-stranded RNAs that modify gene expression at the post-transcriptional level. Recent investigations have revealed that miRNAs are closely linked to liver regeneration.
DATA SOURCES: All included studies were obtained from PubMed, Embase, the ScienceDirect databases and Web of Science, with no limitation on publication year. Only studies published in English were considered.
RESULTS: We grouped studies that involved miRNA and liver regeneration into two groups: miRNAs as promoters and as inhibitors of liver regeneration. We summarized the relevant miRNAs separately from the related pathways.
CONCLUSIONS: Blocking or stimulating the pathways of miRNAs in liver regeneration may be novel therapeutic strategies in future regeneration-related liver managements. We may discover additional chemotherapy targets of miRNA.
|
|
|
|
|
|
|
|
|
2016, Vol. 15 
