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| Beneficial effect of refined red palm oil on lipid peroxidation and monocyte tissue factor in HCV-related liver disease: a randomized controlled study |
| Roberto Catanzaro, Nicola Zerbinati, Umberto Solimene, Massimiliano Marcellino, Dheeraj Mohania, Angelo Italia, Antonio Ayala and Francesco Marotta |
Catania, Italy
Author Affiliations: Department of Clinical and Experimental Medicine, Gastroenterology Section, University of Catania, Catania, Italy (Catanzaro R and Italia A); CMP-Medical Center & Laboratories, Pavia, Italy (Zerbinati N); WHO-center for Traditional Medicine & Biotechnology, University of Milano, Milano, Italy (Solimene U); ReGenera Research Group for Aging-Intervention, Milano, Italy (Marcellino M and Marotta F); Department of Research, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, India (Mohania D); and Biochemistry and Molecular Biology, Seville University, Sevilla, Spain (Ayala A)
Corresponding Author: Professor Roberto Catanzaro, MD, PhD, Presidio Ospedaliero Policlinico “G. Rodolico”, U.O.C. di Medicina Interna “A. Francaviglia”, Bldg. n. 4 - I° Floor, Via S. Sofia, 78, 95123 Catania, Italy (Tel: +39-95-3782902; Fax: +39-95-3782376; Email: rcatanza@unict.it) |
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Abstract BACKGROUND: A large amount of endotoxin can be detected in the peripheral venous blood of patients with liver cirrhosis, contributing to the pathogenesis of hepatotoxicity because of its role in oxidative stress. The present study aimed to test the effect of the supplementation with red palm oil (RPO), which is a natural oil obtained from oil palm fruit (Elaeis guineensis) rich in natural fat-soluble tocopherols, tocotrienols and carotenoids, on lipid peroxidation and endotoxemia with plasma endotoxin-inactivating capacity, proinflammatory cytokines profile, and monocyte tissue factor in patients with chronic liver disease.
METHODS: The study group consisted of sixty patients (34 males and 26 females; mean age 62 years, range 54-75) with Child A/B, genotype 1 HCV-related cirrhosis without a history of ethanol consumption, randomly enrolled into an 8-week oral daily treatment with either vitamin E or RPO. All patients had undergone an upper gastrointestinal endoscopy 8 months before, and 13 out of them showed esophageal varices.
RESULTS: Both treatments significantly decreased erythrocyte malondialdehyde and urinary isoprostane output, only RPO significantly affected macrophage-colony stimulating factor and monocyte tissue factor. Liver ultrasound imaging did not show any change.
CONCLUSIONS: RPO beneficially modulates oxidative stress and, not least, downregulates macrophage/monocyte inflammatory parameters. RPO can be safely advised as a valuable nutritional implementation tool in the management of chronic liver diseases.
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2016, Vol. 15 
