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| Perineural dexamethasone does not enhance the analgesic efficacy of ultrasound-guided subcostal transversus abdominis plane block during laparoscopic cholecystectomy |
| Sheng-Hui Huang, Jing Lu, Hong-Yun Gan, Yi Li, Yong-Gang Peng and Shuan-Ke Wang |
Lanzhou, China
Author Affiliations: Department of Anesthesiology (Huang SH and Li Y) and Department of Orthopedics (Wang SK), Second Hospital of Lanzhou University, Lanzhou 730030, China; Department of Anesthesiology, Sichuan Provincial People’s Hospital and Sichuan Academy of Medical Sciences, Chengdu 610072, China (Lu J); Morphology Teaching and Research Section, Medical School, Northwest University for Nationalities, Lanzhou 730000, China (Gan HY); Department of Anesthesiology, Shands Hospital at the University of Florida, Florida, USA (Peng YG)
Corresponding Author: Shuan-Ke Wang, MD, Department of Orthopedics, Second Hospital of Lanzhou University, Lanzhou 730030, China (Email: wsk2zzy@126.com) |
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Abstract BACKGROUND: Ultrasound-guided transversus abdominis plane (TAP) block is an adjunct therapy to provide effective postoperative analgesia in abdominal surgical procedures. Dexamethasone is a supplement agent that can improve the efficacy of local anesthesia. However, information about its additive effect is limited. This study aimed to compare the analgesic efficiency using ultrasound-guided TAP block with and without perineural dexamethasone for patients who underwent laparoscopic cholecystectomy.
METHODS: Sixty patients who underwent laparoscopic cholecystectomy were randomly divided into three groups: group I, controls; group II, TAP; and group III, TAP+perineural dexamethasone supplement. The requirement of additional analgesia and the first-time request of rescue-analgesia were recorded after operation and the numerical rating scale was evaluated at specific intervals.
RESULTS: Compared to group I, the first-time requirement of rescue-analgesia in groups II and III was significantly delayed (403.0±230.9, 436.0±225.3 vs 152.3±124.7, P<0.01). Compared with those in group I, patients in groups II and III were associated with lower numerical rating scale pain scores (P<0.01) and less postoperative analgesic consumption (P<0.01). There was no significant difference in the variables mentioned above between groups II and III (P>0.05).
CONCLUSION: Perineural dexamethasone has no additive/synergistic effect with subcostal TAP block on analgesic efficacy for the patients undergoing laparoscopic cholecystectomy.
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2016, Vol. 15 
