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| Postoperative day one serum alanine aminotransferase does not predict patient morbidity and mortality after elective liver resection in non-cirrhotic patients |
| Ricky Harminder Bhogal, Amit Nair, Davide Papis, Zaed Hamady, Jawad Ahmad, For Tai Lam, Saboor Khan and Gabriele Marangoni |
Coventry, UK
Author Affiliations: Department of Hepato-pancreatico-biliary Surgery, University Hospitals of Coventry and Warwickshire, Clifford Bridge Road, Coventry, West Midlands, CV2 2DX, UK (Bhogal RH, Nair A, Papis D, Hamady Z, Ahmad J, Lam FT, Khan S and Marangoni G); and University of Birmingham, Centre for Liver Research, Institute for Biomedical Research, The Medical School, Edgbaston, Birmingham, West Midlands, B15 2TT, UK (Bhogal RH)
Corresponding Author: Gabriele Marangoni, MD, Department of Hepato-pancreatico-biliary Surgery, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry, West Midlands, CV2 2DX, UK (Tel: +44-2476965269; Fax: +44-2476965150; Email: Gabriele.Marangoni@uhcw.nhs.uk) |
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Abstract Serum aminotransferases have been used as surrogate markers for liver ischemia-reperfusion injury that follows liver surgery. Some studies have suggested that rises in serum alanine aminotransferase (ALT) correlate with patient outcome after liver resection. We assessed whether postoperative day 1 (POD 1) ALT could be used to predict patient morbidity and mortality following liver resection. We reviewed our prospectively held database and included consecutive adult patients undergoing elective liver resection in our institution between January 2013 and December 2014. Primary outcome assessed was correlation of POD 1 ALT with patient’s morbidity and mortality. We also assessed whether concurrent radiofrequency ablation, neoadjuvant chemotherapy and use of the Pringle maneuver significantly affected the level of POD 1 ALT. A total of 110 liver resections were included in the study. The overall in-hospital patient morbidity and mortality were 31.8% and 0.9%, respectively. The median level of POD 1 ALT was 275 IU/L. No correlation was found between POD 1 serum ALT levels and patient morbidity after elective liver resection, whilst correlation with mortality was not possible because of the low number of mortalities. Patients undergoing concurrent radiofrequency ablation were noted to have an increased level of POD 1 serum ALT but not those given neoadjuvant chemotherapy and those in whom the Pringle maneuver was used. Our study demonstrates POD 1 serum ALT does not correlate with patient morbidity after elective liver resection.
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2016, Vol. 15 
