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| Risk factor analysis of post-ERCP cholangitis: A single-center experience |
| Min Chen a, Lei Wang a, Yun Wang a, Wei Wei b, Yu-Ling Yao a, Ting-Sheng Ling a, Yong-Hua Shen a, Xiao-Ping Zou a,∗ |
a Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
b Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China
∗ Corresponding author.
E-mail address: zouxiaoping795@hotmail.com (X.-P. Zou). |
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Abstract Background: Endoscopic retrograde cholangiopancreatography (ERCP) may have complications. Our study aimed to investigate the risk factors and prevention of post-ERCP cholangitis.
Methods: We retrospectively analyzed 4234 cases undergone ERCP in the Affiliated Drum Tower Hospital of Nanjing University Medical School from January 2008 to December 2013. Patient-related factors and procedure-related factors were analyzed to find the risk factors of post-ERCP cholangitis. The time point of post-ERCP cholangitis was also analyzed. Univariate and multivariate analyses were performed to define the independent risk factors of post-ERCP cholangitis.
Results: The success rate of ERCP was 96.8% (4099/4234). The overall complication rate was 9.4% (399/4234). Post-ERCP cholangitis occurred in 102 cases (2.4%, 102/4234). The most dangerous time of post-ERCP cholangitis was from 24 h–48 h after ERCP (45.1%, 46/102). Univariate analysis revealed that age, hypertension, diabetes, previous ERCP history, biliary stent insertion, pancreatography, endoscopic sphincterotomy, balloon dilation and hilar obstruction were risk factors of post-ERCP cholangitis (P<0.05). Multivariate analysis indicated that age, previous ERCP history and hilar obstruction were independent risk factors (P<0.05). While endoscopic stone extraction was the potential protective factor.
Conclusions: Many risk factors are involved in post-ERCP cholangitis. Among them, old age, previous ERCP history and hilar obstruction were independently related to this post-ERCP complication.
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2018, Vol. 17 
