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| Comments on: Perioperative von Willebrand factor dynamics are associated with liver regeneration and predict outcome after liver resection |
| Jia-Jia Chen a,b, Lan-Juan Li a,b |
a State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
b Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China
∗ Corresponding author at: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
E-mail address: ljli@zju.edu.cn (L.-J. Li). |
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Abstract Recently the article “Perioperative von Willebrand factor dynamics are associated with liver regeneration and predict outcome after liver resection” was published in Hepatology [1]. Prof. Starlinger et al. aimed to assess the association of von Willebrand factor (vWF) levels and clinical outcome in patients with liver cancers post-liver resection (LR). Based on the mechanism that platelets accumulation in the liver may promote liver regeneration after partial LR in mice, they found the vWF-dependent pattern of platelets accumulation during liver regeneration in patients after surgery. The vWF-antigen (vWF-Ag) level is increased after surgery in similar patterns in patients with or without basic liver disease. Baseline vWF-Ag is higher in patients with cirrhosis than those without fibrosis. Compared to patients with low vWF-Ag, those with high preoperative vWF-Ag have worse postoperative liver function, need prolonged intensive care unit stay and hospital stay, and have high mortality rate. Another finding is that high preoperative levels of vWF-Ag is a marker of underlying chronic liver disease and/or subclinical portal hypertension because of its high correlation with increasing levels of soluble CD163, another noninvasive marker for portal hypertension.
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2018, Vol. 17 
