|
|
|
| Is irreversible electroporation safe and effective in the treatment of hepatobiliary and pancreatic cancers? |
| Li-Ming Wu, Le-Le Zhang, Xin-Hua Chen, Shu-Sen Zheng∗ |
Division of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310 0 03, China
∗ Corresponding author.
E-mail address: shusenzheng@zju.edu.cn (S.-S. Zheng). |
|
|
|
Abstract Background: Irreversible electroporation (IRE) is a novel ablative technique for hepatobiliary and pancre- atic cancers. This review summarizes the data regarding the safety and efficacy of IRE in the treatment of hepatobiliary and pancreatic cancers.
Data sources: Studies were identified by searching PubMed and Embase for articles published in English from database inception through July 31, 2017. For inclusion, each clinical study had to report morbidity and survival data on hepatobiliary and pancreatic cancers treated with IRE and contain at least 10 pa- tients. Studies that met these criteria were included for analysis. Two authors assessed each clinical study for data extraction. The controversial parts were resolved through discussion with seniors.
Results: A total of 24 clinical studies were included. Fourteen focused on hepatic ablation with IRE com- prising 437 patients with 666 lesions of different tumor types. Two patients (0.5%) died after the IRE procedure. Morbidity of hepatic ablation with IRE ranged from 7% to 35%. Most complications were mild. Complete response for hepatic tumors was reported as 57%–97%. Ten studies with 455 patients focused on pancreatic IRE. The overall mortality of IRE in pancreatic cancer was 2%. Overall severe morbidity of IRE in pancreatic cancer ranged from 0 to 20%. The median overall survival after IRE ranged from 7 to 23 months. Patients treated with IRE combined with surgical resection showed a longer overall survival.
Conclusions: IRE significantly improves the prognosis of advanced hepatobiliary and pancreatic malig- nances, and companied with less complications. Hence, IRE is a relatively safe and effective non-thermal ablation strategy and potentially recommended as an option for therapy of patients with hepatobiliary and pancreatic malignances.
|
|
|
|
|
|
|
|
|
2019, Vol. 18 
