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| Unexpected mediastinal mass in a liver transplanted patient |
| Giuseppe Losurdo a , Giuseppe Ingravallo b , Antonio Mongelli a , Nicola Maurizio Castellaneta a , Antonio Pisani a , ∗ |
a Section of Gastroenterology, Department of Emergency and Organ Transplantation, University “Aldo Moro”, Piazza G. Cesare 11, 70124 Bari, Italy
b Section of Pathology, Department of Emergency and Organ Transplantation, University “Aldo Moro”, Piazza G. Cesare 11, 70124 Bari, Italy
∗ Corresponding author.
E-mail address: pisann@libero.it (A. Pisani). |
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Abstract The risk of de novo cancer increases by 2 to 7-fold after liver transplantation [1] . The most common de novo cancers are both solid (non-melanoma skin cancers, colorectal carcinoma, genito-urinary and head-neck cancer) [2,3] as well as hematologic malignancies, in particular the so-called post-transplant lymphoproliferative disorder [4] . Immunosuppressive regimen could be the most important cause for increased cancer risk, since currently used drugs lead to a chronic impairment of immune-surveillance against cancer, thus promoting proliferation and survival of malignant cellular clones [5] . Recurrence of hepatocellular carcinoma (HCC) in patients transplanted for HCC within Milan criteria is another aspect of the oncologic scenario related to post-transplant period. Indeed, about 10% of liver recipients experience HCC recurrence, and this event is associated to male gender, size of HCC, vascular invasion and viral hepatitis [6] . We report a case who developed a mediastinal solid malignancy 7 years after liver transplantation.
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2019, Vol. 18 
