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| Simple cholangitis induces extremely and recurrently elevated serum carbohydrate antigen 19-9 level |
| Ding-Li Xu a , Yi-Qun Wu b , Chang Xin c , Qi-Feng Zhou c , Ming-Liang Chen c , Huan-Jun Yan c , ∗ |
a Medical School of Ningbo University, Ningbo 315211, China
b Department of Digestive System, Ningbo Yinzhou No.2 Hospital, Ningbo 315100, China
c Department of Hepatopancreatobiliary Surgery, Yin Zhou People’s Hospital, Ningbo 315040, China
∗ Corresponding author.
E-mail address: 13819816167@139.com (H.-J. Yan). |
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Abstract The carbohydrate antigen 19-9 (CA19-9) is a tumor maker which is usually used in biliary and pancreatic malignancies [1] . However, the specificity of CA19-9 can be reduced by biliary inflammation and other benign diseases [2] . Generally, the level of CA19-9 in benign diseases is less than 100 U/mL, whereas the serum level of CA19-9 can rise to 500 U/mL or even higher than 1000 U/mL in some cases with chronic pancreatitis [3] . Marrelli et al. [4] reported that CA19-9 may be elevated in 61% of benign cases. Moreover, the level of CA19-9 may rise to over 10 0 0 U/mL in patients with choledocholithiasis. Sheen-Chen et al. [5] reported a case of acute cholangitis with extremely elevated serum CA19-9 (5673.8 U/mL). After one month of treatment, the level of CA19-9 returned to normal (10.4 U/mL). We reported here a patient with simple cholangitis who had recurrent elevations of CA19-9 which is rare in previous studies.
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2019, Vol. 18 
