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| Immunometabolic inflammation and hepatocellular carcinoma |
| Jia-Xi Mao, Fei Teng, Cong Liu, Hang Yuan, Jia-Yong Dong, Hong Fu, Guo-Shan Ding, Wen-Yuan Guo ∗ |
Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Naval Medical University, Shanghai 200003, China
∗ Corresponding author.
E-mail address: guowenyuan@smmu.edu.cn (W.-Y. Guo). |
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Abstract Inflammation-cancer transformation and metabolomics are hot topics in hepatocellular carcinoma (HCC). Cancer-related inflammation and anti-cancer immunity co-exist in cancer progression and the microenvironmental conditions dictate the direction [1]. Recently, a study published in CA Cancer J Clin [2] revealed the correlation between excess body weight and increased incidence of tumors. In excess body weight related tumors, the cases of liver cancer ranked first in males and the fourth in females [2], and more direct evidence indicated that non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome are important risk factors of HCC, in addition to hepatitis C/B virus and alcoholic liver disease [3,4]. The crosstalk between immunity and metabolism during the oncogenesis and progression of HCC remains uncertain and deserves further exploration.
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2019, Vol. 18 
