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| Compared efficacy of University of Wisconsin and histidine-tryptophan-ketoglutarate solutions in ex-situ liver resection and autotransplantation for end-stage hepatic alveolar echinococcosis patients |
| Shadike Apaer a , b , Tuerhongjiang Tuxun a , b , Tao Li b , Tuerganaili Aji c , Jiangduosi Payiziwula b , Jin-Ming Zhao b , Ying-Mei Shao c , Hao Wen a , b , c , d , ∗ |
a State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi 830011, China
b Department of Liver Transplantation and Laparoscopic Surgery, Center of Digestive and Vascular Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
c Department of Hepatobiliary and Hydatid Surgery, Center of Digestive and Vascular Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
d WHO Collaborating Center for Prevention and Care Management of Echinococcosis, the First Affiliated Hospital of Xinjiang Medical University and Xinjiang Center for Disease Control, Urumqi 830054, China
∗ Corresponding author at: State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi 830011, China.
E-mail address: dr.wenhao@163.com (H. Wen). |
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Abstract Background: The University of Wisconsin (UW) and histidine-tryptophan-ketoglutarate (HTK) solutions are the two most frequently used liver graft preservation fluids. The present study aimed to compare their efficacy in end-stage hepatic alveolar echinococcosis patients who underwent ex-situ liver resection and autotransplantation (ELRA).
Methods: A total of 81 patients received ELRA from August 2010 to March 2018. They were allocated into UW ( n = 48) and HTK groups ( n = 33) based on the type of solutions used. Demographic and operational data were retrospectively analyzed. Primary outcomes included 90-day mortality, incidence of early graft loss, primary dysfunction, and postoperative complications.
Results: Demographic and operational characteristics were similarly distributed in the two groups. No statistically significant differences were observed with regard to 90-day mortality (12.77% vs. 12.12%) and early graft loss rate (8.51% vs. 9.09%) between the two groups. Patients in the UW and HTK groups showed a primary dysfunction rate of 27.66% and 27.27%, respectively. The UW group exhibited a higher incidence tendency of biliary complications, albeit with no statistical significance.
Conclusions: This is the largest cohort study comparing the efficacy of the UW and HTK organ-preserving solutions in end-stage hepatic alveolar echinococcosis patients in ELRA settings. UW and HTK solutions presented similar efficacy and safety. A randomized clinical trial with larger scale is needed for further investigation in future clinical applications.
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| Cite this article: |
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Apaer S,
Tuxun T,
Li T,
et al.
Compared efficacy of University of Wisconsin and histidine-tryptophan-ketoglutarate solutions in ex-situ liver resection and autotransplantation for end-stage hepatic alveolar echinococcosis patients.
Hepatobiliary Pancreat Dis Int
2019;
18(5):
430-438. DOI:10.1016/j.hbpd.2019.07.001
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| URL: |
| http://dx.doi.org/10.1016/j.hbpd.2019.07.001 OR http://www.hbpdint.com/EN/Y2019/V18/I5/430 |
| [1] |
Jin LM, Zhang YH, Zhang CW, Wu WD, Wu J, Dou CW, Wei FQ, Wang ZF, Hu ZM, Zheng SS. Is laparoscopic radical cholecystectomy an effective and safe approach for advanced gallbladder cancer?[J]. Hepatobiliary Pancreat Dis Int, 2020, 19(3): 203-204. |
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2019, Vol. 18 
