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Accuracy of pipeline blood glucose monitoring in patients with severe liver injury undergoing artificial liver support system treatment |
Hua-Fen Zhang a , b , Zhong-Yang Xie a , c , Xiao-Xi Ouyang a , c , Xiao-Wei Xu a , b , Xiao-Yan Wang a , b , Jian-Rong Huang a , b , Lan-Juan Li a , c , ∗ |
a State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou
310003, China
b Department of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
c Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine,
Hangzhou 310003, China
∗ Corresponding author.
E-mail address: ljli@zju.edu.cn (L.-J. Li). |
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Abstract Severe deterioration of liver function in patients can be characterized by coagulation disorders, jaundice, hepatic encephalopathy, ascites, and other symptoms. Severe liver injury can develop as acute liver failure, subacute liver failure, acute-on-chronic liver failure, or further worsening of end-stage liver disease [1] . Liver transplant is the standard therapy for patients with severe liver injury; however, it is hampered by a shortage of organ donors, complications caused by post-transplant immune rejection, and high cost [2] . Artificial liver support system (ALSS), based on the principle of temporarily replacing liver function, have been proposed as new therapeutic options to treat severe liver injury. In the past few decades, various types of ALSSs have been developed and applied to the treatment of severe liver injury [3] . These include plasma exchange (PE), the molecular adsorbent recirculating system (MARS), and the double plasma molecular adsorption system (DPMAS) [4] . Li’s artificial liver system (Li-ALSS), is a kind of ALSS that organically coupled by plasma exchange, plasma adsorption, and hemofiltration [5] . DPMAS is a part of Li-ALSS that combines two hemoperfusion columns to efficiently remove toxins from the plasma [6] .
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