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| MicroRNAs and long non-coding RNAs in liver surgery: Diagnostic and therapeutic merits |
| Zhi-Qiu Hu a , b , # , Yi Lu b , c , # , Di Cui c , Chen-Yang Ma c , Su Shao d , Ping Chen e , Ran Tao b , c , Jian-Jun Wang d , ∗ |
a Department of Surgery, Minhang Hospital, Fudan University, Shanghai 201199, China
b Department of Hepatobiliary-Pancreatic & Minimally Invasive Surgery, Affiliated Zhejiang Provincial People’s Hospital, Hangzhou Medical School, Hangzhou 310014, China
c Center for Clinical Medical Research, Affiliated Zhejiang Provincial People’s Hospital, Hangzhou Medical School, Hangzhou 310014, China
d Department of General Surgery, Chun’an 1st People’s Hospital, Hangzhou 311700, China
e Department of Obstetrics and Gynecology, Shaoxing 2nd Hospital, Shaoxing 312000, China
∗ Corresponding author.
E-mail address: wjj0714@163.com (J.-J. Wang).
# Contributed equally. |
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Abstract Background: Hepatectomy and liver transplantation (LT) are the two most commonly performed surgical procedures for various hepatic lesions. microRNA (miRNA) and long non-coding RNA (lncRNA) have been gradually unveiled their roles as either biomarkers for early diagnosis or potentially therapeutic tools to manipulate gene expression in many disease entities. This review aimed to discuss the effects of miRNA or lncRNA in the hepatectomy and LT fields.
Data sources: We did a literature search from 1990 through January 2018 to summarize the currently available evidence with respect to the effects of miRNA and lncRNA in liver regeneration after partial hep- atectomy, as well as their involvement in several key issues related to LT, including ischemia-reperfusion injury, allograft rejection, tolerance, recurrence of original hepatic malignancies, etc.
Results: Certain miRNAs and lncRNAs are actively involved in the regulation of various aspects of liver resection and transplantation. During the process of liver regeneration after hepatectomy, the expression of miRNAs and lncRNAs shows dynamic changes.
Conclusions: It is now clear that miRNAs and lncRNAs orchestrate in various aspects of the pathophys- iological process of LT and hepatectomy. Better understanding of the underlying mechanism and future clinical trials may strengthen their positions as either biomarkers or potential therapeutic targets in the management of complications after liver surgery.
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2020, Vol. 19 
