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Sinusoidal obstruction syndrome related to tacrolimus following liver transplantation |
Li Li a , b , # , Yue Dong c , # , Rui-Dong Li a , b , # , Yi-Feng Tao a , b , Cong-Huan Shen a , b , Zheng-Xin Wang a , b , ∗ |
a Department of General Surgery, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China
b Institute of Organ Transplantation, Fudan University, Shanghai 200040, China
c Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai 200040, China
∗ Corresponding author at: Department of General Surgery, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, 20 0 040 Shanghai, China.
E-mail address: wangzhengxin@huashan.org.cn (Z.-X. Wang).
# Contributed equally. |
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Abstract Sinusoidal obstruction syndrome (SOS), also known as venoocclusive disease, is characterized by fibrotic occlusion of small hepatic veins and congestion of sinusoids [1] . This syndrome is mainly observed in hematopoietic stem cell transplantation (HSCT) and its incidence in liver transplantation (LT) ranges from 1.9% to 2.9% [2,3] . Although rare, severe SOS following LT can cause liver graft dysfunction with poor prognosis [3] .
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