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| Two-in-one: A pooled analysis of primary hepatic neuroendocrine carcinoma combined/collided with hepatocellular carcinoma |
| Jia-Xi Mao # , Fei Teng # , Ke-Yan Sun # , Cong Liu # , Guo-Shan Ding, Wen-Yuan Guo ∗ |
Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Navy Medical University, Shanghai 200003, China
∗ Corresponding author.
E-mail address: guowenyuan@smmu.edu.cn (W.-Y. Guo).
# Contributed equally. |
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Abstract Primary hepatic neuroendocrine carcinoma (PHNEC) combined/ collided with hepatocellular carcinoma (HCC) is a rare and intriguing disease with characteristics of two histologically different cancers. Usually, a combined type refers to the cases in which hepatic neuroendocrine carcinoma (HNEC) and HCC components intermingle with each other and cannot be clearly separated in the transitional areas, while a collision type refers to those in which the two distinct cancers occurred simultaneously and independently. Sometimes it is difficult to readily distinguish these two types. We searched PubMed, Medline, China Science Periodical Database, and VIP Database with the publication from January 1980 to January 2019, using the keywords (“hepatic neuroendocrine carcinoma” or “HNEC”) and (“hepatocellular carcinoma” or “HCC”). After manually excluding records on secondary HNEC and other types of liver cancer, a total of 28 cases in 24 reports [1–24] were identified and summarized in Table 1 . The current summary thus aimed to provide more information about the clinical manifestations, managements and prognosis of this rare disease.
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2020, Vol. 19 
