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| Serum non-high-density lipoprotein cholesterol level is increased in Chinese patients with nonalcoholic fatty liver disease |
| Si-Yu Shao a , Yi-Lan Wang b , c , Li-Min Feng b , c , Ying Zhao b , c , ∗ |
a School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, China
b Department of Clinical Laboratory, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
c Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou 310003, China
∗ Corresponding author at: Department of Clinical Laboratory, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310 0 03, China.
E-mail address: yingzhao@zju.edu.cn (Y. Zhao). |
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Abstract Nonalcoholic fatty liver disease (NAFLD) is a growing public health problem globally. Although the primary liver pathology in NAFLD patients is associated with an increased risk of overall mortality, the majority of deaths in NAFLD patients are due to the cardiovascular disease (CVD) [1]. With the change of lifestyle, the prevalence of NAFLD in China is increasing and patients tend to be younger [2] . A relevant epidemiological survey has shown that the prevalence of NAFLD in adults is estimated to be 12%–24% in Asia [3] . Non-high-density lipoprotein cholesterol (non-HDL-C) refers to the sum of all cholesterol subtracts high-density lipoprotein cholesterol (HDL-C), which can more comprehensively reflect the comprehensive metabolic changes of lipoproteins including low-density lipoprotein cholesterol (LDL-C), intermediate-density lipoprotein cholesterol (IDL-C), and very-low-density lipoprotein cholesterol (VLDL-C) [4]. Recently, NAFLD that often coexists with dyslipidemia has been identified as a major modifiable risk factor of CVD, and non-HDL-C has become a new biomarker for assessing and predicting the risk of CVD [4]. Therefore, we used the data from health checkup and examined the relationship between the serum non-HDL-C level and NAFLD.
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2020, Vol. 19 
