|
|
|
| Prediction of Clostridium difficile infection based on gut microbial traits in patients with Clostridium difficile colonization |
| Dong Yan a , Yan-Di Huang b , Yun-Bo Chen a , Tao Lv a , Chun-Xia Zhu a , Jian-Rong Huang a , Lan-Juan Li a , ∗ |
a State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center
for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University
School of Medicine, Hangzhou 310003, China
b Department of Laboratory Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
∗ Corresponding author.
E-mail address: ljli@zju.edu.cn (L.-J. Li). |
|
|
|
|
Abstract Cirrhotic patients usually require multiple hospitalizations due to upper gastrointestinal hemorrhage, abdominal infection, and hepatic encephalopathy. These patients need long-term hospital stay, and long-term application of proton pump inhibitors and antibiotics, which may result in Clostridium difficile infection (CDI) [1]. To our best knowledge, Clostridium difficile colonization (CDC) is the major risk factor for the pathogenesis of CDI. Our previous study demonstrated that 19.8% patients with hepatic cirrhosis have CDC, and about 26% of the CDC patients may develop CDI during hospitalization [2]. In cirrhotic patients, gut microbial structure and diversity may lead to overgrowth of intestinal bacteria, which may trigger the overgrowth of conditioned pathogens and opportunistic infection [3]. The antibiotics could further destroy the gut microbiota which makes the intestinal tract vulnerable to the growth of pathogenic bacteria [4]. A previous study showed that decline of gut microbial diversity and structural changes were the main etiology of CDI [5]. In this study, we aimed to analyze the roles of gut microbial traits in the pathogenesis of CDI among patients carrying Clostridium (C.) difficile .
|
|
|
|
|
|
|
|
|
2021, Vol. 20 
