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| Acute hepatitis associated with increased atypical lymphocyte |
| Hai-Yan Sun a , Hai-Jiang Tong a , Da-Wei Cui b , ∗ |
a Department of Clinical Laboratory, Shaoxing Second Hospital, Shaoxing 312000, China
b Department of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
∗ Corresponding author.
E-mail address: daweicui@zju.edu.cn (D.-W. Cui). |
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Abstract Hepatitis A and hepatitis E are acute infectious diseases caused by hepatitis A virus (HAV) and hepatitis E virus (HEV), which are mainly transmitted through the fecal-oral route [1]. The early clinical symptoms of patients with hepatitis A or E are nonspecific, including fever, chills, abdominal pain, diarrhea, and rash [2]. Moreover, the levels of specific laboratory diagnostic biomarkers, such as serum anti-HAV/HEV IgM antibodies, are too low to be detectable which make the early diagnosis difficult [1,3]. These patients are sometimes misdiagnosed in the early stage which result in inappropriate treatments [1]. Atypical lymphocyte is most common in Epstein-Barr virus (EBV) infection [4,5]. However, there are few reports of atypical lymphocyte caused by hepatitis virus. In this study, we report two cases of acute hepatitis with atypical lymphocyte to provide values for the diagnosis of the disease.
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2021, Vol. 20 
