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| Involvement of the circular RNA/microRNA/glucose-6-phosphate dehydrogenase axis in the pathological mechanism of hepatocellular carcinoma |
| Ying Wang a , # , Xin-Yi Zhou a , # , Xiang-Yun Lu b , Ke-Da Chen a , Hang-Ping Yao b , ∗ |
a Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, China
b State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
∗ Corresponding author.
E-mail address: yaohangping@zju.edu.cn (H.-P. Yao).
# Contributed equally. |
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Abstract Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide with high mortality. The incidence of HCC is increasing in China. Abnormal activation of glucose-6-phosphate dehydrogenase (G6PD) exists in all malignant tumors, including HCC, and is closely related to the de- velopment of HCC. In addition, the differential expression of non-coding RNAs is closely related to the development of HCC. This systematic review focuses on the relationship between G6PD, HCC, and non- coding RNA, which form the basis for the circRNA/miRNA/G6PD axis in HCC. The circular RNA (cir- cRNA)/microRNA (miRNA)/G6PD axis is involved in development of HCC. We proposed that non-coding RNA molecules of the circRNA/miRNA/G6PD axis may be novel biomarkers for the pathological diagnosis, prognosis, and targeted therapy of HCC.
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Xiao LL, Wu XX, Chen JJ, Yan D, Shi DY, Huang JR, Xu XW, Li LJ. Progress in hepatitis B virus-related acute-on-chronic liver failure treatment in China: A large, multicenter, retrospective cohort study using a propensity score matching analysis ?[J]. Hepatobiliary Pancreat Dis Int, 2021, 20(6): 535-541. |
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2021, Vol. 20 
