|
|
|
| High perioperative lactate levels and decreased lactate clearance are associated with increased incidence of posthepatectomy liver failure |
| Mihai Popescu a , b , Simona Dima c , ∗, Vladislav Brasoveanu c , Andrada Tudor b , Mihai Simionescu b , Dana Tomescu a , b |
a “Carol Davila” University of Medicine and Pharmacy, Bucharest 020021, Romania
b Department of Anesthesia and Intensive Care, Fundeni Clinical Institute, Bucharest 022328, Romania
c “Dan Setlacec” Center for General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest 022328, Romania
∗ Corresponding author.
E-mail address: dima.simona@gmail.com (S. Dima). |
|
|
|
|
Abstract Extensive liver resection represents a life-saving intervention in patients with primary or secondary liver tumors. Recent advances made in the field of chemotherapy and surgical techniques have translated into a greater number of patients who are older and with more complex comorbidities presenting for major liver surgery [1] and thus having an increased risk of perioperative mortality. Of those, posthepatectomy liver failure (PHLF) represents a life-threatening complication of liver surgery and one of the most important causes of perioperative mortality. The incidence reported in current literature varies between 4.9% and 32% [2,3]. Such patients need to be managed by a multidisciplinary team in a dedicated intensive care unit to minimize multi-organ dysfunction associated with PHLF [4] . We hypothesized that lactate dynamics in the setting of liver surgery can be used as a marker of poor liver function. This study aimed to assess the correlation between lactate levels, lactate kinetics and postoperative PHLF in the perioperative period of major hepatic surgery.
|
|
|
|
|
|
|
|
|
2021, Vol. 20 
