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| Glucagonoma syndrome with necrolytic migratory erythema as initial manifestation |
| Wei-Fang Zhu a , Shu-Sen Zheng b , ∗ |
a Department of Dermatology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
b Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
∗ Corresponding author.
E-mail address: shusenzheng@zju.edu.cn (S.-S. Zheng). |
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Abstract Necrolytic migratory erythema (NME) is a group of cutaneous lesions characterized by periodic episodes of annular or figurative dark red plaques, which are typically accompanied by blisters, erosions, and crusting. It is often associated with glucagonoma. Glucagonoma is an extremely rare neuroendocrine tumor that arises from pancreatic islet α cells and manifests as elevated glucagon, with an incidence of about 1 in 20 million per year [1,2]. Glucagonoma with NME is defined as glucagonoma syndrome (GS), and the presence of skin lesions helps in the timely diagnosis and treatment of pancreatic tumors [3,4]. Here we reported a case of GS with NME as initial manifestation aiming to improve our understanding of GS and achieve an early diagnosis.
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2021, Vol. 20 
