|
|
|
| Liver involvement in the course of thymoma-associated multiorgan autoimmunity: The first histological description |
| Fabrizio Citarella a , ∗, Umberto Vespasiani-Gentilucci b , Anna Crescenzi c , Antonella Bianchi c , Vladimir Virzi a , Giuseppe Tonini a |
a Department of Medical Oncology, Policlinico Universitario Campus Bio-Medico, via Alvaro del Portillo, Rome 00128, Italy
b Area of Internal Medicine, Unit of Hepatology, Policlinico Universitario Campus Bio-Medico, via Alvaro del Portillo, Rome 00128, Italy
c Unit of Pathology, Policlinico Universitario Campus Bio-Medico, via Alvaro del Portillo, Rome 00128, Italy
∗ Corresponding author.
E-mail address: f.citarella@unicampus.it (F. Citarella). |
|
|
|
|
Abstract Thymoma-associated multiorgan autoimmunity (TAMA) is a rare paraneoplastic syndrome described in patients with thymoma and characterized by multiorgan failure and graft-versus-host disease (GVHD) like pathology affecting the skin, the gastrointestinal tract, and the liver. To date, only 21 cases are reported in literature [1], with some patients presenting gastrointestinal and hepatic manifestations, mainly colitis, diarrhea, and abnormal liver enzymes, but the hepatic involvement has not been histologically characterized yet. In the present study, we describe for the first time that liver involvement in a patient affected by TAMA resembles GVHD.
|
|
|
|
|
|
|
|
|
2022, Vol. 21 
