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| Nanosecond pulsed electric field interrupts the glycogen metabolism in hepatocellular carcinoma by modifying the osteopontin pathway |
| Shen Hu a , # , Yan Zhu b , # , Yu Chen c , Pu Cheng d , Gui-Rong Wang e , Li-Quan Wang a , ∗, Xin-Mei Chen f |
a Department of Obstetrics, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China
b Department of Respiratory, Shulan Hospital, Hangzhou 310004, China
c Department of Pediatric Surgery, Guangdong Women and Children Hospital, Guangzhou 511400, China
d Department of Gynecology, the Second Affiliated Hospital, Zhejiang University, Hangzhou 310052, China
e Department of Surgery, the State University of New York, Upstate Medical University, Syracuse, New York, USA
f School of Pharmacy, Shandong University of Chinese Medicine, Jinan 250355, China
∗ Corresponding author.
E-mail address: wangliquan@zju.edu.cn (L.-Q. Wang).
# Contributed equally. |
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Abstract Hepatocellular carcinoma (HCC) is one of the most common lethal cancers and is the leading cause of cancer mortality worldwide [1]. In recent years, developments in locoregional therapies have provided new options for the treatment of HCC, which are recommended by the international guidelines including the Barcelona Clinic Liver Cancer (BCLC) and the American Joint Committee on Cancer (AJCC) [2]. For locoregional therapies, radiofrequency ablation (RFA) is the most commonly used method which is based on thermal ablation. Although RFA is a minimal invasive treatment, the damage of adjacent normal tissues caused by the thermal effect occasionally occurs during treatment. Research has also revealed that the heat might promote tumor dissemination [3]. Thus, there is urgent need to find new non-thermal ablation method for HCC treatment. Unlike RFA, the temperature rise caused by nanosecond pulsed electric field (nsPEF) does not exceed 3 °C [4], which greatly reduces thermal damage to surrounding tissues. In addition, nsPEF has great capability to initiate antitumor immune reaction [5] . The current study aimed to investigate the therapeutic effect of nsPEF and the possible molecular mechanism on glycogen metabolism of nsPEF in HCC.
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2022, Vol. 21 
