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| Preoperative lymphocyte to C-reactive protein ratio as a new prognostic indicator in patients with resectable gallbladder cancer |
| Wen-Yan Yao a , b , # , Xiang-Song Wu a , b , # , Shi-Lei Liu a , b , Zi-You Wu a , b , Ping Dong a , b , Wei Gong a , b , ∗ |
a Department of General Surgery, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
b Shanghai Key Laboratory of Biliary Tract Disease Research, Shanghai 200092, China
∗ Corresponding author.
E-mail address: gongwei@xinhuamed.com.cn (W. Gong).
# Contributed equally. |
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Abstract Background: Inflammation is often related to cancer, and several inflammatory scores have been established to predict the prognosis of various types of cancer. Our study aimed to determine the prognostic value of the preoperative lymphocyte to C-reactive protein ratio (LCR) for predicting postoperative outcomes in patients with resectable gallbladder cancer (GBC).
Methods: A retrospective analysis of 104 GBC patients who received curative surgery at Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine from January 20 0 0 to December 2016 was performed. A time-dependent receiver operating characteristic curve was constructed to evaluate the accuracy of different markers. Univariate and multivariate Cox proportional hazard models were used to define factors associated with overall survival.
Results: Among the assessed variables, the preoperative LCR showed the highest accuracy in predicting the overall survival of GBC patients (AUC: 0.736). Decreased preoperative LCR was significantly associated with advanced tumor stage, including tumor invasion ( P = 0.018), lymph node metastasis ( P = 0.011) and TNM stage ( P = 0.022). A low preoperative LCR (cutoffthreshold = 145.5) was an independent risk factor for overall survival in patients with resectable GBC ( P < 0.001).
Conclusions: The preoperative LCR is a novel and valuable prognostic indicator of postoperative survival in patients with resectable GBC.
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2022, Vol. 21 
