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| Successful liver transplantation from a donor with immune thrombocytopenia |
| Wen-Tao Yang, Jing-Sheng Ma, Hong-Fei Zhu, Lin Zhong, Qi-Gen Li ∗ |
Department of Organ Transplantation, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China
∗ Corresponding author.
E-mail address: qigenli@hotmail.com (Q.-G. Li). |
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Abstract Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disease, which results from a combination of humoral and cell-mediated attacks on platelets and megakaryocytes [1–3]. ITP patients are always presented as heterogeneous clinical bleeding manifestations. Fatal bleeding such as intracranial hemorrhage is the main cause of death, which turns the patients into potential organ donors. Several studies indicated that the donor lymphocytes secreting autoantibody may be transferred to recipients after transplantation [4,5]. Transplantation-mediated alloimmune thrombocytopenia (TMAT) was donor-derived thrombocytopenia after solidorgan transplantation [6]. TMAT is a rare complication after transplantation, and the recipients of TMAT may present more severe bleeding events than the donors. A total of 6 recipients with TMAT after liver transplantation from ITP donors have been reported internationally [6–11], among which 3 recipients died and 3 survived. Thus, liver transplantation from ITP donors is relatively risky, and as a marginal donor organ, the use of ITP donor liver is controversial. There are no relevant guidelines for the safety assessment and treatment of ITP donor liver transplantation up to now. Here we reported a successful case with TMAT in liver transplant recipient from ITP donor in purpose of improving our understanding of TMAT.
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2022, Vol. 21 
