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| Ultrasound-guided in vivo porcine liver ablation with nanosecond pulsed electric fields |
| Jun-Jie Huang a , b , Rong-Wei Ma c , Da-Zhi Li a , b , Sheng-Yong Yin a , b , Zhen Liu c , Lin Zhou a , b , Ke-Ping Yan c , Shu-Sen Zheng a , b , ∗ |
a Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
b NHC Key Laboratory of Combined Multi-organ Transplantation, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003,
China
c Institute of Industrial Ecology and Environment, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310028, China
∗ Corresponding author at: Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
E-mail address: shusenzheng@zju.edu.cn (S.-S. Zheng). |
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Abstract In recent decades, local ablative therapies have evolved considerably and played an increasingly important role in the treatment of inoperable tumors. Conventional modalities are mainly based on thermal ablation to destroy targeted lesions, such as radiofrequency ablation [1]. The clinical application of pulsed electric fields [2] is emerging as an innovative and promising technique for tumor ablation, which does not depend on heat energy and preserves surrounding tissues adjacent to tumors [3]. Highvoltage ultrashort electric pulses compromise the integrity of the plasma membrane and destroy intracellular homeostasis. Nanosecond pulsed electric fields (nsPEFs), with a strength of several tens of kV/cm and a nanosecond duration, have attracted much attention and been extensively studied in cancer ablation [4,5]. Furthermore, using nsPEFs to ablate tumors can elicit a systemic antitumor immune response against recurrence and metastasis [6]. In this study, a novel repetitive nsPEF generator was introduced and applied to planar cell treatment and porcine liver ablation. We aimed to investigate the feasibility and efficacy of tissue ablation with this device and the safety during the perioperative period.
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2022, Vol. 21 
