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| Microbiological cultures and antimicrobial prophylaxis in patients
undergoing total pancreatectomy with islet cell autotransplantation |
| Kristen R Szempruch a , Anne M Lachiewicz b , Brittney M Williams c , Aman Kumar c , Xavier Baldwin c , Chirag S Desai c ,∗ |
a Pharmacy Department, University of North Carolina Medical Center, Chapel Hill, NC, USA
b Division of Infectious Disease, University of North Carolina Medical Center, Chapel Hill, NC, USA
c Department of Surgery, Transplant, University of North Carolina Medical Center, Chapel Hill, NC, USA
∗ Corresponding author.
E-mail address: chirag_desai@med.unc.edu (C.S. Desai). |
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Abstract Total pancreatectomy with islet cell autotransplantation (TPIAT) is a viable treatment option upon failed endoscopic and medical therapy for patients with chronic pancreatitis. This procedure involves surgical removal of the entire pancreas, isolation of islet cells and re-infusion of these cells into the liver via portal vein [1,2]. The risk of contamination to the final islet cell product can occur at several stages of the isolation procedure [3]. In order to ensure the sterility of the islet cell product, multiple samples from the preservation and cannulation solution, and the final islet cell product are sent for bacterial cultures. Prior studies have found variable clinical consequences of these cultures on infectious complications or graft function [3–9]. Herein we aimed to determine the incidence of infection in 60 days post-TPIAT and its association with the culture data.
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2023, Vol. 22 
