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A new prognostic model for drug-induced liver injury especially suitable for Chinese population |
Yan-Fei Chen, Lan-Juan Li ∗ |
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
∗ Corresponding author.
E-mail address: ljli@zju.edu.cn (L.-J. Li). |
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Abstract Drug-induced liver injury (DILI) is a rare side effect of drugs caused by all kinds of prescription or over-the-counter chemicals, biological agents, traditional Chinese medicine (TCM), natural medicine (NM), health products, dietary supplements and their metabolites, and even excipients, which can lead to jaundice, liver failure, or even death. Although it is rare in term of single drug, the occurrence of DILI in all liver injuries is not low due to the wide range of drugs and foods involved. Moreover, there was an increasing trend of incidence of DILI since 2010 worldwide, with Asian regions showing the highest incidence [1].
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