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| Expression of platelet endothelial cell adhesion molecule-1 between pancreatic microcirculation and peripheral circulation in rats with acute edematous pancreatitis |
| Hong-Kai Gao, Zong-Guang Zhou, You-Qin Chen, Fang-Hai Han and Cun Wang |
Chengdu, China
From the Department of General Surgery and Institute of Digestive Surgery, West China Hospital, Sichuan University, Chengdu 610041, China (Gao HK, Zhou ZG, Chen YQ, Han FH and Wang C)
Correspondence: Hong-Kai Gao, MD, Department of General Surgery and Institute of Digestive Surgery, West China Hospital, Sichuan University, Chengdu 610041, China (Tel: 86-28-85422484; Email: tone257@yahoo.com.cn) |
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Abstract OBJECTIVE: To study the changes of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in peripheral circulation and pancreatic microcirculation in rats with acute edematous pancreatitis (AEP).
METHODS: The model of AEP was established with 50 Wistar rats, and the changes of PECAM-1 expression on PMNs from the splenic vein and inferior vena cava were determined by flow cytometry.
RESULTS: PECAM-1 expression on PMNs showed no significant difference between pancreatic microcirculation and peripheral circulation at AEP2h and AEP4h time points. From the AEP4h to the AEP8h time point, PECAM-1 expression in peripheral circulation was up-regulated, but PECAM-1 expression in pancreatic microcirculation was down-regulated. PECAM-1 expression had a significant difference between pancreatic microcirculation and peripheral circulation at the AEP8h time point (P<0.05).
CONCLUSION: PECAM-1 expression on PMNs is in a converse way between pancreatic microcirculation and peripheral circulation in AEP.
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| Cite this article: |
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Gao HK,
Zhou ZG,
Chen YQ,
et al.
Expression of platelet endothelial cell adhesion molecule-1 between pancreatic microcirculation and peripheral circulation in rats with acute edematous pancreatitis.
Hepatobiliary Pancreat Dis Int
2003;
2(3):
463-466. DOI:
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| URL: |
| http://dx.doi.org/ OR http://www.hbpdint.com/EN/Y2003/V2/I3/463 |
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2003, Vol. 2 
