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| Outcomes in children with biliary atresia following liver transplantation |
| Li-Ying Sun, Yun-Sheng Yang, Zhi-Jun Zhu, Wei Gao, Lin Wei, Xiao-Ye Sun, Wei Qu, Wei Rao, Zhi-Gui Zeng, Chong Dong, Jin-Peng Tu, Jian Wang, Yi-He Liu, Yuan Liu, Li-Xin Yu, Yu Wang, Jing Li and Zhong-Yang Shen |
Tianjin, China
Author Affiliations: Nankai University School of Medicine, Tianjin 300071, China (Sun LY and Yang YS); Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China (Sun LY and Yang YS); Department of Organ Transplantation, Tianjin First Central Hospital, Tianjin 300192, China (Sun LY, Zhu ZJ, Gao W, Wei L, Sun XY, Qu W, Rao W, Zeng ZG, Dong C, Tu JP, Wang J, Liu YH, Liu Y, Yu LX, Wang Y, Li J and Shen ZY)
Corresponding Author: Yun-Sheng Yang, MD, PhD, Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China (Tel: 86-10-55499005; Fax: 86-10-55499005; Email: sunny301ddc@126.com) |
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Abstract BACKGROUND: Congenital biliary atresia is a rare condition characterized by idiopathic dysgenesis of the bile ducts. If untreated, congenital biliary atresia leads to liver cirrhosis, liver failure and premature death. The present study aimed to evaluate the outcomes of orthotopic liver transplantation in children with biliary atresia.
METHOD: We retrospectively analyzed 45 patients with biliary atresia who had undergone orthotopic liver transplantation from September 2006 to August 2012.
RESULTS: The median age of the patients was 11.0 months (5-102). Of the 45 patients, 41 were younger than 3 years old. Their median weight was 9.0 kg (4.5-29.0), 34 of the 45 patients were less than 10 kg. Thirty-one patients had undergone Kasai portoenterostomy prior to orthotopic liver transplantation. We performed 30 living donor liver transplants and 15 split liver transplants. Six patients died during a follow-up. The median follow-up time of surviving patients was 11.4 months (1.4-73.7). The overall 1-, 2- and 3-year survival rates were 88.9%, 84.4% and 84.4%, respectively.
CONCLUSION: With advances in surgical techniques and management, children with biliary atresia after liver transplantation can achieve satisfactory survival in China, although there remains a high risk of complications in the early postoperative period.
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2013, Vol. 12 
