|
|
|
| HBV recurrence lowered by lamivudine/HBIG combination therapy in liver transplant patients: ten-year experience |
| Chun-Hui Yuan, Dian-Rong Xiu, Bin Jiang, Zhi-Fei Li, Lei Li, Shi-Bing Song and Tong-Lin Zhang |
Beijing, China
Author Affiliations: Department of General Surgery, Peking University Third Hospital, Beijing 100191, China (Yuan CH, Xiu DR, Jiang B, Li ZF, Li L, Song SB and Zhang TL)
Corresponding Author: Dian-Rong Xiu, MD, PhD, Department of General Surgery, Peking University Third Hospital, Beijing 100191, China (Tel: 86- 10-82267338; Fax: 86-10-62010334; Email: ychdoctor@163.com) |
|
|
|
|
Abstract BACKGROUND: Lamivudine and hepatitis B immunoglobulin (HBIG) are widely used to treat patients with hepatitis B recurrence after liver transplantation. However, the outcomes are inconclusive. The present study was undertaken to evaluate the effect of combined therapy on patients with hepatitis B recurrence after liver transplantation.
METHODS: Twenty-two patients with hepatitis B recurrence after liver transplantation from August 2000 to October 2011 were enrolled in this study. Of these patients, 16 received lamivudine plus HBIG (combination therapy group) and 6 were treated with lamivudine alone (lamivudine-treated group). The clinical features were matched in the two groups. HBV recurrence parameters, HBsAg clearance rate, patient survival rate, and survival time were compared.
RESULTS: The average time of follow-up was 47.2 months (range 13-99). Significant difference was noted in the HBsAg clearance rate in the lamivudine-treated and combination therapy groups (50% vs 93.8%, P<0.05). There was no significant difference in the time of HBV recurrence, patient survival rate and survival time between lamivudine-treated and combination therapy groups (P>0.05).
CONCLUSION: Compared with lamivudine monotherapy, combination therapy significantly increased the HBsAg clearance rate in patients with HBV recurrence after liver transplantation.
|
|
|
|
|
|
|
|
|
2013, Vol. 12 
