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| A new nomogram for predicting lymph node positivity in pancreatic cancer |
| Xiao-Dong Tian, Yin-Mo Yang ∗ |
Department of General Surgery, Peking University First Hospital, Beijing 100034, China
∗ Corresponding author.
E-mail address: yangyinmo@263.net (Y.-M. Yang). |
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Abstract Pancreatic cancer (PC) is one of the most dismal malignancies, and radical resection in combination with perioperative systemic chemotherapy provides the only chance of long-term survival [1]. However, surgeons have been increasingly aware that some anatomically resectable PC patients cannot benefit from upfront surgery. The majority of PC patients with radical resection will suffer from local recurrence or systematic metastasis in 1-2 years after surgery, especially for those with pathological positive lymph nodes (LNs) [2]. Hence, the preoperative identification of PC patients with LN metastasis is essential for either prognosis prediction or administration of neoadjuvant chemotherapy or radiochemotherapy. However, it is reported that approximately 70% of PC patients who were clinically diagnosed as node negative finally proved to have nodal involvement upon pathological evaluation, indicating that the radiological staging of nodule involvement before surgery is still difficult [3]. Therefore, the development of prediction models for preoperative determination of pathological LN positivity in resectable PC patients has potential significance for optimizing the individualized comprehensive treatment strategies before surgery.
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2021, Vol. 20 
