Predictive value of C-reactive protein/albumin ratio in acute pancreatitis
Mustafa Kaplan, Ihsan Ates, Muhammed Yener Akpinar, Mahmut Yuksel, Ufuk Baris Kuzu, Sabite Kacar, Orhan Coskun and Ertugrul Kayacetin
Ankara, Turkey
Author Affiliations: Department of Gastroenterology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara 06100, Turkey (Kaplan M, Akpinar MY, Yuksel M, Kuzu UB, Kacar S, Coskun O and Kayacetin E); Department of Internal Medicine, Ankara Numune Training and Research Hospital, Ankara 06100, Turkey (Ates I)
Corresponding Author: Ihsan Ates, MD, PhD, Department of Internal Medicine, Ankara Numune Training and Research Hospital, Ankara 06100, Turkey (Tel: +0903125084666; Fax: +0903123113958; Email: dr.ihsanates@hotmail.com)
Abstract：BACKGROUND: Serum C-reactive protein (CRP) increases and albumin decreases in patients with inflammation and infection. However, their role in patients with acute pancreatitis is not clear. The present study was to investigate the predictive significance of the CRP/albumin ratio for the prognosis and mortality in acute pancreatitis patients.
METHODS: This study was performed retrospectively with 192 acute pancreatitis patients between January 2002 and June 2015. Ranson scores, Atlanta classification and CRP/albumin ratios of the patients were calculated.
RESULTS: The CRP/albumin ratio was higher in deceased patients compared to survivors. The CRP/albumin ratio was positively correlated with Ranson score and Atlanta classification in particular and with important prognostic markers such as hospitalization time, CRP and erythrocyte sedimentation rate. In addition to the CRP/albumin ratio, necrotizing pancreatitis type, moderately severe and severe Atlanta classification, and total Ranson score were independent risk factors of mortality. It was found that an increase of 1 unit in the CRP/albumin ratio resulted in an increase of 1.52 times in mortality risk. A prediction value about CRP/albumin ratio >16.28 was found to be a significant marker in predicting mortality with 92.1% sensitivity and 58.0% specificity. It was seen that Ranson and Atlanta classification were higher in patients with CRP/albumin ratio >16.28 compared with those with CRP/albumin ratio ≤16.28. Patients with CRP/albumin ratio >16.28 had a 19.3 times higher chance of death.
CONCLUSION: The CRP/albumin ratio is a novel but promising, easy-to-measure, repeatable, non-invasive inflammation-based prognostic score in acute pancreatitis.
. [J]. Hepatobiliary Pancreat Dis Int, 2017, 16(4): 424-430.
Kaplan M, Ates I, Akpinar MY, Yuksel M, Kuzu UB, Kacar S, Coskun O, Kayacetin E. Predictive value of C-reactive protein/albumin ratio in acute pancreatitis. Hepatobiliary Pancreat Dis Int, 2017, 16(4): 424-430.
2017, Vol. 16 
