Role of the postoperative cholesterol in early allograft dysfunction and survival after living donor liver transplantation
Jian Yang, Hai-Qing Wang, Jia-Yin Yang, Tian-Fu Wen, Bo Li, Wen-Tao Wang and Lu-Nan Yan
Chengdu, China
Author Affiliations: Department of Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610041, China (Yang J, Wang HQ, Yang JY, Wen TF, Li B, Wang WT and Yan LN)
Corresponding Author: Wen-Tao Wang, MD, PhD, Department of Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610041, China (Tel/Fax: +86-28-85422867; Email: wangwt2002@yeah.net)
Abstract：BACKGROUND: Many studies have confirmed that serum total cholesterol (sTC) concentrations were associated with underlying liver damage and the synthesis capacity of liver. However, the role of postoperative sTC level on evaluating graft function and predicting survival of recipients who underwent liver transplantation has not been discussed.
METHODS: Clinical data of 231 living donor liver transplantation recipients from May 2003 to January 2015 were retrospectively collected. Patients were stratified into the low sTC group (sTC <1.42 mmol/L, 57 recipients) and high sTC group (sTC ≥1.42 mmol/L, 174 recipients) according the sTC level on postoperative day 3 based on receiver-operating characteristic curve analysis. The clinical characteristics and postoperative short- and long-term outcomes were compared between the two groups.
RESULTS: Recipients with sTC <1.42 mmol/L experienced more severe preoperative disease conditions, a higher incidence of postoperative early allograft dysfunction (38.6% vs 10.3%, P<0.001), 90-day mortality (28.1% vs 10.9%, P=0.002) and severe complications (29.8% vs 17.2%, P=0.041) compared to recipients with sTC ≥1.42 mmol/L. The multivariate analysis demonstrated that sTC <1.42 mmol/L had a 4.08-fold (95% CI: 1.83-9.11, P=0.001) and 2.72-fold (95% CI: 1.23-6.00, P=0.013) greater risk of developing allograft dysfunction and 90-day mortality, and patients with sTC <1.42 mmol/L had poorer overall recipient and graft survival rates at 1-, 3-, and 5-year than those with sTC ≥1.42 mmol/L (67%, 61% and 61% vs 83%, 71% and 69%, P=0.025; 65%, 59% and 59% vs 81%, 68% and 66%, P=0.026, respectively). Cox multivariate analysis showed that sTC <1.42 mmol/L was an independent predicting factor for total recipient survival (HR=2.043; 95% CI: 1.173-3.560; P=0.012) and graft survival (HR=1.905; 95% CI: 1.115-3.255; P=0.018).
CONCLUSIONS: sTC <1.42 mmol/L on postoperative day 3 was an independent risk factor of postoperative early allograft dysfunction, 90-day mortality, recipient and graft survival, which can be used as a marker for predicting postoperative short- and long-term outcomes.
. [J]. Hepatobiliary Pancreat Dis Int, 2017, 16(6): 610-616.
Yang J, Wang HQ, Yang JY, Wen TF, Li B, Wang WT, Yan LN. Role of the postoperative cholesterol in early allograft dysfunction and survival after living donor liver transplantation. Hepatobiliary Pancreat Dis Int, 2017, 16(6): 610-616.
2017, Vol. 16 
