High perioperative lactate levels and decreased lactate clearance are associated with increased incidence of posthepatectomy liver failure
Mihai Popescu a , b , Simona Dima c , ∗, Vladislav Brasoveanu c , Andrada Tudor b , Mihai Simionescu b , Dana Tomescu a , b
a “Carol Davila” University of Medicine and Pharmacy, Bucharest 020021, Romania
b Department of Anesthesia and Intensive Care, Fundeni Clinical Institute, Bucharest 022328, Romania
c “Dan Setlacec” Center for General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest 022328, Romania
∗ Corresponding author.
E-mail address: dima.simona@gmail.com (S. Dima).
Abstract：Extensive liver resection represents a life-saving intervention in patients with primary or secondary liver tumors. Recent advances made in the field of chemotherapy and surgical techniques have translated into a greater number of patients who are older and with more complex comorbidities presenting for major liver surgery [1] and thus having an increased risk of perioperative mortality. Of those, posthepatectomy liver failure (PHLF) represents a life-threatening complication of liver surgery and one of the most important causes of perioperative mortality. The incidence reported in current literature varies between 4.9% and 32% [2,3]. Such patients need to be managed by a multidisciplinary team in a dedicated intensive care unit to minimize multi-organ dysfunction associated with PHLF [4] . We hypothesized that lactate dynamics in the setting of liver surgery can be used as a marker of poor liver function. This study aimed to assess the correlation between lactate levels, lactate kinetics and postoperative PHLF in the perioperative period of major hepatic surgery.
引用本文:
. [J]. Hepatobiliary Pancreat Dis Int, 2021, 20(6): 592-594.
Popescu M, Dima S, Brasoveanu V, Tudor A, Simionescu M, Tomescu D. High perioperative lactate levels and decreased lactate clearance are associated with increased incidence of posthepatectomy liver failure. Hepatobiliary Pancreat Dis Int, 2021, 20(6): 592-594.
2021, Vol. 20 
