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Chinese expert consensus on organ protection of transplantation (2022 edition) |
Jian-Hui Li a , Xiao Xu b , Yan-Feng Wang c , Hai-Yang Xie d , Jing-Yu Chen e , Nian-Guo Dong f , Mitesh Badiwala g , Li-Ming Xin h , Roberto Vanin Pinto Ribeiro g , Hao Yin i , Hao Zhang j , k , Jian-Zheng Zhang j , k , Feng Huo l , Jia-Yin Yang m , Hong-Ji Yang n , Hui Pan o , Shao-Guang Li j , k , Yin-Biao Qiao d , Jia Luo d , Hao-Yu Li d , Jun-Jun Jia p , Hao Yu p , Han Liang c , Si-Jia Yang o , Hao Wang j , k , Zhong-Yang Liu j , k , Li-Cheng Zhang j , k , Xiao-Yi Hu p , Hao Wu p , Yi-Qing Hu p , Pei-Fu Tang j , k , Qi-Fa Ye c , Shu-Sen Zheng a , d , p , ∗ |
a Department of Hepatobiliary and Pancreatic Surgery, Department of Liver Transplantation, Shulan (Hangzhou) Hospital, Zhejiang Shuren University School
of Medicine, Hangzhou 310022, China
b Department of Hepatobiliary and Pancreatic Surgery, Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China
c Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key
Laboratory of Medical Technology on Transplantation, Wuhan 430062, China
d NHC Key Laboratory of Combined Multi-organ Transplantation, Hangzhou 310003, China
e Wuxi Lung Transplantation Center, Wuxi People’s Hospital Affiliated with Nanjing Medical University, Wuxi 214023, China
f Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
g Peter Munk Cardiac Centre, Toronto General Hospital-University Health Network, Toronto, Canada
h School of Computer Engineering and Science, Shanghai University, Shanghai 200444, China
i Organ Transplant Center, Shanghai Changzheng Hospital, Shanghai 200003, China
j Department of Orthopedics, Chinese PLA General Hospital, Beijing 100039, China
k National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Beijing 100039, China
l Department of Surgery, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510040, China
m Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610041, China
n Organ Transplantation Center, Sichuan Provincial People’s Hospital and School of Medicine, University of Electronic Science and Technology of China,
Chengdu 610072, China
o Department of Lung Transplantation, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
p Division of Hepatobiliary Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
∗ Corresponding author at: Department of Hepatobiliary and Pancreatic Surgery, Department of Liver Transplantation, Shulan (Hangzhou) Hospital, Zhejiang Shuren University School of Medicine, Hangzhou 310022, China.
E-mail address: shusenzheng@zju.edu.cn (S.-S. Zheng) . |
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Abstract Organ transplantation increases survival and improves quality of life to many patients with end-stage organ failure. Organ shortage is a worldwide problem that restricts organ transplantation [1]. Organ procurement and preservation as well as ischemia-reperfusion injury (IRI) after transplantation are the important factors affecting prognosis of recipients. Since the development of organ transplantation technology in the 20th century, organ protection technology has been a most promising concept in this field. Organ preservation solutions such as the Collins solution, University of Wisconsin (UW) solution, and histidinetryptophan- ketoglutarate (HTK) solution were developed sequentially [2], which developed rapidly in static cold storage (SCS) techniques. SCS remains the standard preservation technique for organ transplantation [2], but it invariably leads to a progressive decline in organ viability and function. It also precludes dynamic assessment of organ function to determine the adequacy for transplantation.
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