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| Perspective: Advances in liver transplantation for hepatocellular carcinoma – A prototype for transplant oncology |
| John Fung ∗, Diego DiSabato , Chih-Yi Liao , Osmanuddin Ahmed , Anjana Pillai |
Liver Tumor Center, The University of Chicago Medicine, Chicago 60637, IL, USA
∗ Corresponding author.
E-mail address: jfung@surgery.bsd.uchicago.edu (J. Fung).
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Abstract In his 1969 book, Experience in Hepatic Transplantation , Thomas E Starzl wrote: “the unequivocal indication for the operation of liver replacement was originally considered to be primary hepatic malignancy which could not be treated with conventional techniques of subtotal liver resection” [1]. Thus, it was not surprising that many cases in the early reported series of orthotopic liver transplantation (OLT) were for malignant indications [2-4]. As these procedures were done during the developmental phase of OLT, characterized by a host of technical, immunological, infectious risk factors, along with the advanced cancer staging of these early cases, the overall outcomes were poor. In the 1983 NIH Consensus Development Conference on Liver Transplantation, the committee noted: “Primary hepatic malignancy confined to the liver but not amenable to resection may be an indication for transplantation. Results to date indicate a strong likelihood of recurrence of that malignancy” [5].
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2023, Vol. 22 
