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| The role of targeting protein for Xklp2 in tumorigenesis of hepatocellular carcinoma |
| Ting Li a , b , # , Lu-Jian Zhu a , # , An-Min Huang b , Yi-Feng Wei b , Jun Xu b , Ye-Jin Xu a , ∗ |
a Department of Infectious Diseases, Jinhua Municipal Central Hospital, Jinhua 321000, China
b School of the First Clinical Medical Sciences (School of Information and Engineering), Wenzhou Medical University, Wenzhou 325035, China
∗ Corresponding author.
E-mail address: xuyejin-fox@163.com (Y.-J. Xu) .
# Contributed equally. |
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Abstract Hepatocellular carcinoma (HCC) is a prevalent form of gastrointestinal malignancies. The current combination of immunotherapy and other treatments improves overall survival compared to conventional therapies, but the immunosuppressive microenvironment of HCC is a significant barrier to the efficacy of immunotherapeutic drugs [1]. Tumor immune escape is promoted by interactions among immunosuppressive cells, including tumor-associated macrophages, marrow-derived suppressor cells, tumor-associated neutrophils, cancer-associated fibroblasts, and tumor-infiltrating Tregs [2].
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2023, Vol. 22 
