The role of the gut microbiome in chronic liver diseases: Present insights and future outlook

doi:10.1016/j.hbpd.2023.09.003

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Abstract The human gastrointestinal tract harbors trillions of microbes including bacteria, viruses, and fungi that facilitate digestion and nutrient absorption, thereby affecting host metabolism and immunity. The liver communicates with the gut through portal vein, systemic circulation, and biliary tract to form the gut-liver axis [1]. The liver receives 70%-75% of its blood supply from the portal vein, positioning it as the first organ to encounter gut-derived microbes, microbial products, and toxins when microflora balance and gut barrier function are disrupted, which could contribute to the development of chronic liver diseases [2]. While alterations in gut microbial composition have been noted across various diseases, the causal connections remain elusive, and there are situations where the absence of microbiota does not impact the disease progression [3]. Therefore, it is imperative to review the role of gut microbiota and its products in pathogenesis of liver diseases such as nonalcoholic fatty liver disease (NAFLD), drug-induced liver injury (DILI), and cholestatic liver disease, etc.

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	Jiang L
	Fan JG

Cite this article:

Jiang L, Fan JG. The role of the gut microbiome in chronic liver diseases: Present insights and future outlook. Hepatobiliary Pancreat Dis Int 2023; 22(5): 441-443. DOI:10.1016/j.hbpd.2023.09.003

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http://dx.doi.org/10.1016/j.hbpd.2023.09.003 OR http://www.hbpdint.com/EN/Y2023/V22/I5/441