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| Mechanisms of liver injuries caused by traditional Chinese medicines |
| Shui-Fang Jin a , Qi Pan b , Jin-Peng Zhou c , Xiao-Ping Pan b , ∗ |
a Intensive Care Unit, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou
310006, China
b Institute of Liver Diseases, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China
c The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310056, China
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Abstract Drug-induced liver injury (DILI) is a common adverse drug reaction, which can even result in liver failure [1,2]. The Chinese Medical Association issued the Guidelines for the Diagnosis and Treatment of DILI based on the Roussel Uclaf Causality Assessment Method (RUCAM) in 2015 [3]. A previous study reported that traditional Chinese medicines (TCMs), herbal and dietary supplements, and antituberculosis drugs were the main causes of DILI in China [4]. Herb-induced liver injury (HILI) refers to liver injury caused by TCMs, natural drugs, and their related preparations [5]. With much more widespread applications of Chinese herbal medicine and continuous improvements in adverse drug reaction monitoring systems, the number of cases of HILI is increasing, which has become an important factor leading to DILI [4,5].
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2024, Vol. 23 
